Principal Scientist, ADME-PK
Company: Dyne Therapeutics
Location: Waltham
Posted on: March 6, 2026
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Job Description:
Company Overview: Dyne Therapeutics is focused on delivering
functional improvement for people living with genetically driven
neuromuscular diseases. We are developing therapeutics that target
muscle and the central nervous system (CNS) to address the root
cause of disease. The company is advancing clinical programs for
Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1
(DM1) as well as a preclinical programs for facioscapulohumeral
muscular dystrophy (FSHD) and Pompe disease. At Dyne, we are on a
mission to deliver functional improvement for individuals, families
and communities. Learn more at https://www.dyne-tx.com/ , and
follow us on X , LinkedIn and Facebook . Role Summary: The
Principal Scientist, ADME-PK in Preclinical Development (PCD)
department utilizes their knowledge in drug metabolism, ADME
concepts, pharmacokinetics, pharmacodynamic and bioanalytical
principles to advance Dyne’s efforts surrounding delivery of
therapeutic payloads to muscle and CNS tissues with the FORCE
platform. This role is based in Waltham, MA. Primary
Responsibilities Include: Design and execute internal/external
preclinical studies to understand the pharmacokinetics (PK) and
absorption, metabolism, distribution, and excretion (ADME) of
Dyne’s drug candidates Represent PCD as the ADME-PK subject matter
expert on discovery and program teams Partner with and support
Research, Toxicology, Translational Biomarkers, Clinical,
Regulatory, Project Management and other Dyne departments
Collaborate with Clinical Pharmacology/Pharmacometrics to develop
quantitative tools to translate PK/PD relationship from preclinical
to clinical Author high quality Regulatory documents including
INDs, CTAs, and NDA/BLA filings. Prepare strategic and
science-based ADME strategies that meet regulatory requirements and
program goals Facilitate strategic scientific communication via
meetings, abstracts and manuscripts Education and Skill
Requirements: PhD in Pharmacokinetics, Pharmacology, Pharmaceutics,
Biomedical Sciences or other relevant field with >6 years (MS
with >8 years, BS with >12 years) of experience in the
biopharmaceutical industry, with evidence of drug development
experience Strong knowledge of drug metabolism, ADME concepts,
pharmacokinetics, pharmacodynamics and bioanalytical principles
Familiarity with regulatory submission including FIH dosing
strategy is highly desirable Proficient in using WinNonlin or other
pharmacokinetic software Excellent communication (verbal and
written) and presentation skills, as well as interpersonal skills
and the ability to represent PCD in a team environment Experience
with PK characterization of protein therapeutics or antibody-drug
conjugates (ADCs) is desired LI-Onsite MA Pay Range $159,000 -
$195,000 USD The pay range reflects the base pay range Dyne
reasonably expects to pay for this role at the time of posting.
Individual compensation depends on factors such as education,
experience, job-related knowledge, and demonstrated skills. The
statements contained herein reflect general details as necessary to
describe the principles functions for this job, the level of
knowledge and skill typically required, and the scope of
responsibility, but should not be considered an all-inclusive
listing of work requirements. Individuals may perform other duties
as assigned, including work in other functional areas to cover
absences or relief, to equalize peak work periods or otherwise
balance workload. Dyne Therapeutics is an equal opportunity
employer and will not discriminate against any employee or
applicant on the basis of age, color, disability, gender, national
origin, race, religion, sexual orientation, veteran status, or any
classification protected by federal, state, or local law.
Keywords: Dyne Therapeutics, Attleboro , Principal Scientist, ADME-PK, Science, Research & Development , Waltham, Massachusetts
