Senior Director, Global Health Economics & Outcomes Research

Location: Waltham
Posted on: June 23, 2025

Job Description:

Company Overview: Dyne Therapeutics is discovering and advancing innovative life-transforming therapeutics for people living with genetically driven neuromuscular diseases. Leveraging the modularity of its FORCE™ platform, Dyne is developing targeted therapeutics that deliver to muscle and the central nervous system (CNS). Dyne has a broad pipeline for neuromuscular diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD) and preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. Role Summary: The Senior Director, Global Health Economics & Outcomes Research (HEOR), is an experienced and strategic leader who is responsible for leading the development and execution of HEOR strategies for our early and late phase programs. This strategic leader establishes the overarching HEOR strategy in alignment with the market access and commercialization strategy and has a proven track record of generating evidence to support market access for global pharmaceutical products. They create effective and productive partnership with cross-functional partners to influence strategic clinical development and commercialization decisions, as well as driving and executing HEOR research strategies to create and communicate compelling evidence supporting the differential value of Dyne assets for payer and HTA stakeholders across all stages of the product lifecycle. The person in this role has strong leadership skills, a broad understanding and deep experience of global pharmaceutical markets (US & global markets) and a proven track record of bringing products to market successfully. This role is based in Waltham, MA without the possibility of being a fully remote role. Primary Responsibilities Include: HEOR lead on cross-functional teams to ensure global HEOR strategic plans reflect input of key stakeholders and are aligned with commercial, R&D, clinical, regulatory, medical, RWE, and market access plans Development and execution of high quality HEOR evidence and value communication strategies to support optimal funding, reimbursement and patient access Oversee evidence generation including, CEAs and BIMs, prospective and retrospective observational studies, ITCs, meta-analyses and systematic reviews, PRO measure development and validation, and other research as needed to support product value Identify global HEOR evidence requirements and gaps; design, conduct and deliver studies, models, and tools to support value demonstration and product differentiation for assigned indication(s) Collaborate with Medical Affairs and Communications teams on publication strategy and ensure that dissemination of HEOR evidence is timely and has optimal impact Provide key input to the design of clinical development programs to ensure appropriate inclusion of design elements and endpoints relevant to payers, clinicians and patients Develop and communicate compelling value narratives and evidence packages for payers, health technology assessment (HTA) bodies, and other stakeholders Support the development of clinical, economic, and patient-centered product value propositions; deliver compelling and robust global launch deliverables that support market access (including GVD, AMCP Dossiers) Develop payer customer-facing value demonstration tools that meet regulatory standards and train the field team(s) for effective delivery Serve as an internal resource for research design, HEOR methodologies, analytic techniques and reporting of health economic and outcomes research Build and contribute to research partnerships with academic institutions, stakeholders, thought-leaders, KOLs, patient groups, customers and contract research organizations to optimize HEOR impact Build, lead and coach a high-performing global HEOR team Set, secure, monitor, and manage all associated budgets Represent Dyne HEOR on key senior-level governance forums and working groups Understand and abide by global compliance regulations Ability to travel globally on a regular basis Education and Skills Requirements: Advanced degree (PhD, MD, MPH, MS or PharmD) in a scientific discipline; preferred Doctorate, Masters or equivalent in health economics, epidemiology, health services research, biostatistics Minimum 12 years of relevant experience in health economics and outcomes research, or a directly-related field and significant experience in direct management or cross functional management 9 years’ experience in people management, with experience building and leading high-performing global teams Excellent written and verbal communication skills Strong track record of publications in peer-reviewed journals Superior strategic/tactical planning experience within a pharmaceutical environment is required with deep experience in commercialization and drug development Excellent communication, presentation, collaboration and influencing skills cross internal and external stakeholders Experience in leading cross-functional teams required Demonstrated relationship building at all levels of the organization and across geographies LI-Onsite The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload. This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values. Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

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