Senior Scientist I, Pipeline Development & SAR Optimization

Company: AbbVie
Location: Cambridge
Posted on: February 2, 2026

Job Description:

Company Description AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas immunology, oncology, neuroscience, and eye care and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at www.abbvie.com . Follow @abbvie on X , Facebook , Instagram , YouTube , LinkedIn and Tik Tok . Job Description At AbbVie, we are dedicated to solving some of the worlds most complex and serious diseases. Our mission is to develop and deliver advanced therapeutics that change lives. We are looking for talented, passionate, and driven individuals to join our Biotherapeutics and Genetic Medicine (BGM) team. As a Senior Scientist in our siRNA group, you will be part of an innovative team focused on advancing RNA-based therapies that have the potential to revolutionize patient care. AbbVie is looking for a Senior Scientist I to join our siRNA group within the Biotherapeutics and Genetic Medicine (BGM) department. This role will involve designing and executing innovative experimental approaches to address key scientific challenges related to oligonucleotide therapeutics. The successful candidate will drive scientific innovation, identify new methods and techniques, and collaborate across functions to support the development of novel RNA-based therapies. Responsibilities Lead research efforts within a cross-functional team to advance new therapeutic targets for siRNA-based pipeline development. Design and execute in vitro and in vivo proof-of-concept studies to evaluate siRNA library and characterize lead compounds for the target engagement and therapeutic benefits. Design and execute structure-activity-relationship (SAR) studies for lead optimization, including optimization of siRNA sequence, chemical modification patterns, conjugation sites and linkers, etc. Provide scientific leadership and expertise in candidate nomination and pipeline development. Work independently and maintain a high level of productivity in the laboratory, ensuring efficiency and scientific rigor. Analyze and interpret multidisciplinary data to generate actionable conclusions and guide future experimental directions. Collaborate and effectively communicate results with key stakeholders and cross-functional teams throughout the organization. Contribute as a primary author to scientific publications, presentations, and/or as a primary inventor of patent applications. Mentor and support junior scientists within the team. Qualifications BS, MS, or PhD inchemistry, molecular biology, biochemistry, or related field with typically 10 years (BS), 8 years (MS), or 0-3 years (PhD) of experience. Demonstrated expertise in siRNA therapeutics, including library design, screening and characterization of SAR. Demonstrated expertise for siRNA candidate nomination and pipeline development. Extensive hands-on experience and techniques for molecular and RNA biology, including cell culture, RNA extraction, RNA quantification (RT-PCR, qPCR, ddPCR), next-generation sequencing (NGS) library preparation, protein assays (ELISA, Western Blot, JESS), flow cytometry and other biomarker quantification. Experience in assay development and high-throughput screening for siRNA target identification and validation, mechanism of action studies, biodistribution and biomarker analysis is a plus. Strong understanding of ex-hepatic delivery of siRNA is highly desirable. Proven ability to develop, troubleshoot and refine assays to enhance sensitivity, reproducibility, and throughput. Highly self-motivated and capable of thriving in a fast-paced, collaborative team environment. Strong written and verbal communication skills, with experience contributing to technical reports, publications, or regulatory documentation. Why AbbVie? AbbVie is a global biopharmaceutical company committed to bringing innovative medicines to patients in need. We offer a collaborative work environment, opportunities for professional growth, and the ability to make an impact on the future of healthcare. Join us and be part of a team that is transforming the landscape of genetic medicine. How to Apply If you are passionate about advancing RNA-based therapeutics and have a track record of success in cell and molecular biology, we encourage you to apply! Please submit your resume outlining your relevant experience and why you would be a great fit for this position. Additional Information Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law: The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeof this posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location, andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees. This job is eligible to participate in our short-term incentiveprograms. Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of any bonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's sole andabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. US & Puerto Rico only - to learn more, visit https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more: https://www.abbvie.com/join-us/reasonable-accommodations.html

Keywords: AbbVie, Attleboro , Senior Scientist I, Pipeline Development & SAR Optimization, Healthcare , Cambridge, Massachusetts